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KMID : 1141520220370040641
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Endocrinology and Metabolism
2022 Volume.37 No. 4 p.641 ~ p.651
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Characteristics of Glycemic Control and Long-Term Complications in Patients with Young-Onset Type 2 Diabetes
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Baek Han-Sang
Park Ji-Yeon
Yu Jin
Lee Joon-Yub
Yang Yeo-Ree
Ha Jeong-Hoon
Lee Seung-Hwan
Cho Jae-Hyoung
Lim Dong-Jun
Kim Hun-Sung
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Abstract
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Background: The prevalence of young-onset diabetes (YOD) has been increasing worldwide. As the incidence of YOD increases, it is necessary to determine the characteristics of YOD and the factors that influence its development and associated complications.
Methods: In this retrospective study, we recruited patients who were diagnosed with type 2 diabetes mellitus between June 2001 and December 2021 at a tertiary hospital. The study population was categorized according to age: YOD (age <40 years), middle-age-onset diabetes (MOD, 40≤ age <65 years), and late-onset diabetes (LOD, age ≥65 years). We examined trends in glycemic control by analyzing fasting glucose levels during the first year in each age group. A Cox proportional-hazards model was used to determine the relative risk of developing complications according to glycemic control trends.
Results: The fasting glucose level at the time of diagnosis was highest in the YOD group (YOD 149±65 mg/dL; MOD 143±54 mg/dL; and LOD 140±55 mg/dL; P=0.009). In the YOD group, glucose levels decreased at 3 months, but increased by 12 months. YOD patients and those with poor glycemic control in the first year were at a higher risk of developing complications, whereas the risk in patients with LOD was not statistically significant.
Conclusion: YOD patients had higher glucose levels at diagnosis, and their glycemic control was poorly maintained. As poor glycemic control can influence the development of complications, especially in young patients, intensive treatment is necessary for patients with YOD.
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KEYWORD
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Diabetes mellitus, Glycemic control, Young aged
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